Recent Publications
Rolli S, Langridge CA, Sontag EM. Clearing the JUNQ: the molecular machinery for sequestration, localization, and degradation of the JUNQ compartment. Front Mol Biosci. 2024;11:1427542. doi: 10.3389/fmolb.2024.1427542. eCollection 2024. PubMed PMID: 39234568; PubMed Central PMCID: PMC11372896.
Mayer MP, Blair L, Blatch GL, Borges TJ, Chadli A, Chiosis G, de Thonel A, Dinkova-Kostova A, Ecroyd H, Edkins AL, Eguchi T, Fleshner M, Foley KP, Fragkostefanakis S, Gestwicki J, Goloubinoff P, Heritz JA, Heske CM, Hibshman JD, Joutsen J, Li W, Lynes M, Mendillo ML, Mivechi N, Mokoena F, Okusha Y, Prahlad V, Repasky E, Sannino S, Scalia F, Shalgi R, Sistonen L, Sontag E, van Oosten-Hawle P, Vihervaara A, Wickramaratne A, Wang SXY, Zininga T. Stress biology: Complexity and multifariousness in health and disease. Cell Stress Chaperones. 2024 Feb;29(1):143-157. doi: 10.1016/j.cstres.2024.01.006. Epub 2024 Feb 3. PubMed PMID: 38311120; PubMed Central PMCID: PMC10939078.
Sontag EM, Morales-Polanco F, Chen JH, McDermott G, Dolan PT, Gestaut D, Le Gros MA, Larabell C, Frydman J. Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear-vacuolar junctions and perinuclear ESCRT. Nat Cell Biol. 2023 May;25(5):699-713. doi: 10.1038/s41556-023-01128-6. Epub 2023 Apr 20. PubMed PMID: 37081164; NIHMSID:NIHMS2091077.
Boeynaems S, Chong S, Gsponer J, Holt L, Milovanovic D, Mitrea DM, Mueller-Cajar O, Portz B, Reilly JF, Reinkemeier CD, Sabari BR, Sanulli S, Shorter J, Sontag E, Strader L, Stachowiak J, Weber SC, White M, Zhang H, Zweckstetter M, Elbaum-Garfinkle S, Kriwacki R. Phase Separation in Biology and Disease; Current Perspectives and Open Questions. J Mol Biol. 2023 Mar 1;435(5):167971. doi: 10.1016/j.jmb.2023.167971. Epub 2023 Jan 21. PubMed PMID: 36690068; PubMed Central PMCID: PMC9970028.
Rolli S, Sontag EM. Spatial sequestration of misfolded proteins in neurodegenerative diseases. Biochem Soc Trans. 2022 Apr 29;50(2):759-771. doi: 10.1042/BST20210862. Review. PubMed PMID: 35311889. Click here for the Accepted version of the manuscript.
Wu GH, Mitchell PG, Galaz-Montoya JG, Hecksel CW, Sontag EM, Gangadharan V, Marshman J, Mankus D, Bisher ME, Lytton-Jean AKR, Frydman J, Czymmek K, Chiu W. Multi-scale 3D Cryo-Correlative Microscopy for Vitrified Cells. Structure. 2020 Nov 3;28(11):1231-1237.e3. doi: 10.1016/j.str.2020.07.017. Epub 2020 Aug 18. PubMed PMID: 32814034; PubMed Central PMCID: PMC7642057.
Samant RS, Livingston CM, Sontag EM, Frydman J. Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control. Nature. 2018 Nov;563(7731):407-411. doi: 10.1038/s41586-018-0678-x. Epub 2018 Oct 31. PubMed PMID: 30429547; PubMed Central PMCID: PMC6707801.
Sontag EM, Samant RS, Frydman J. Mechanisms and Functions of Spatial Protein Quality Control. Annu Rev Biochem. 2017 Jun 20;86:97-122. doi: 10.1146/annurev-biochem-060815-014616. Epub 2017 May 10. Review. PubMed PMID: 28489421.